Naughty Dogin kehittämä Uncharted 2: Among Thieves nousi odotetusti Las Vegasissa järjestetyn Academy of Interactive Arts and Sciences -gaalan tähdeksi. Toimintaseikkailu kahmaisi hurjat kymmenen palkintoa, mukaan lukien vuoden pelin palkinnon.
Muita menestyjiä olivat esimerkiksi Call of Duty: Modern Warfare 2, The Beatles: Rock Band ja Batman: Arkham Asylum. Koko palkintolista löytyy alta.
* Game of the Year: Uncharted 2: Among Thieves
* Outstanding Achievement in Game Direction: Uncharted 2: Among Thieves
* Casual Game of the Year: Flower
* Fighting Game of the Year: Street Fighter IV
* Role-Playing/MMO Game of the Year: Dragon Age: Origins
* Sports Game of the Year: FIFA 10
* Racing Game of the Year: Forza Motorsport 3
* Outstanding Achievement in Game Design: Batman: Arkham Asylum
* Adventure Game of the Year: Uncharted 2: Among Thieves
* Social Networking Game of the Year: Farmville
* Strategy/Simulation Game of the Year: Brütal Legend
* Action Game of the Year: Call of Duty: Modern Warfare 2
* Family Game of the Year: The Beatles: Rock Band
* Outstanding Innovation in Gaming: Scribblenauts
* Outstanding Achievement in Animation: Uncharted 2: Among Thieves
* Outstanding Achievement in Visual Engineering: Uncharted 2: Among Thieves
* Outstanding Achievement in Art Direction: Uncharted 2: Among Thieves
* Outstanding Achievement in Story (Adapted): Batman: Arkham Asylum
* Outstanding Character Performance: Batman: Arkham Asylum (Joker)
* Outstanding Achievement in Online Game Play: Call of Duty: Modern Warfare 2
* Outstanding Achievement in Story (Original): Uncharted 2: Among Thieves
* Outstanding Achievement in Original Music Composition: Uncharted 2: Among Thieves
* Outstanding Achievement in Soundtrack: Brütal Legend
* Outstanding Achievement in Game Play Engineering: Uncharted 2: Among Thieves
* Outstanding Achievement in Sound Design: Uncharted 2: Among Thieves
* Outstanding Achievement in Portable Game Design: Scribblenauts
* Portable Game of the Year: Scribblenauts